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Gary L Firestone Selected Research

indole-3-carbinol

1/2017Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells.
1/2017Inhibition of oncogenic BRAF activity by indole-3-carbinol disrupts microphthalmia-associated transcription factor expression and arrests melanoma cell proliferation.
1/2016Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells.
11/2014The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation.
9/2014Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells.
11/2012Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.
11/2012Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling.
9/2011Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.
8/20101-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells.
6/2010Direct inhibition of elastase activity by indole-3-carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells.
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Gary L Firestone Research Topics

Disease

36Neoplasms (Cancer)
12/2017 - 02/2002
31Breast Neoplasms (Breast Cancer)
05/2016 - 02/2002
8Prostatic Neoplasms (Prostate Cancer)
10/2017 - 06/2003
5Melanoma (Melanoma, Malignant)
12/2017 - 11/2014
4Endometrial Neoplasms (Endometrial Cancer)
03/2014 - 02/2004
3Carcinoma (Carcinomatosis)
01/2009 - 12/2003
2Carcinogenesis
07/2010 - 04/2005
1Residual Neoplasm
11/2014
1Autolysis
08/2010
1Mouth Neoplasms (Oral Cancer)
07/2010
1Bone Neoplasms (Bone Cancer)
02/2009
1Osteoporosis
02/2009
1Malaria
01/2009
1Hypoxia (Hypoxemia)
05/2008

Drug/Important Bio-Agent (IBA)

26indole-3-carbinolIBA
01/2017 - 02/2002
15Proteins (Proteins, Gene)FDA Link
10/2017 - 02/2002
133,3'-diindolylmethane (diindolylmethane)IBA
11/2013 - 03/2002
12indoleIBA
11/2013 - 08/2002
11Estrogens (Estrogen)FDA Link
11/2012 - 08/2002
10PhytochemicalsIBA
12/2017 - 04/2005
8Estrogen Receptor alphaIBA
11/2012 - 01/2004
7Estrogen ReceptorsIBA
04/2010 - 03/2002
6artemisinin (artemisinine)IBA
10/2017 - 12/2008
6Hormones (Hormone)IBA
08/2010 - 01/2004
6GlucocorticoidsIBA
10/2007 - 02/2002
5DNA (Deoxyribonucleic Acid)IBA
12/2017 - 03/2002
5AndrogensIBA
10/2017 - 06/2003
4glucobrassicinIBA
11/2014 - 09/2011
4Pancreatic Elastase (Elastase)IBA
09/2014 - 12/2008
4Antineoplastic Agents (Antineoplastics)IBA
04/2010 - 12/2003
4Estrogen Receptor betaIBA
02/2009 - 01/2004
4Dexamethasone (Maxidex)FDA LinkGeneric
09/2007 - 02/2002
3Microphthalmia-Associated Transcription FactorIBA
12/2017 - 01/2016
3Androgen Receptors (Androgen Receptor)IBA
10/2017 - 11/2005
3CyclinsIBA
03/2014 - 03/2005
3TamoxifenFDA LinkGeneric
08/2010 - 03/2005
3Interferon-gamma (Interferon, gamma)IBA
05/2008 - 03/2005
3beta CateninIBA
10/2007 - 02/2002
3Phosphotransferases (Kinase)IBA
09/2007 - 02/2003
2VemurafenibIBA
12/2017 - 01/2017
2Glycogen Synthase (Synthase I)IBA
12/2017 - 10/2007
2Antimalarials (Antimalarial Agents)IBA
10/2017 - 03/2014
2SesquiterpenesIBA
10/2017 - 10/2009
2LactonesIBA
10/2017 - 10/2009
2Transcription Factors (Transcription Factor)IBA
01/2017 - 01/2003
2Cyclin-Dependent Kinases (cdk Proteins)IBA
12/2015 - 12/2006
2Telomerase (Telomerase Reverse Transcriptase)IBA
12/2015 - 09/2011
2ErbB Receptors (EGF Receptor)IBA
09/2014 - 07/2010
2Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA
11/2012 - 06/2010
2Cyclin EIBA
12/2008 - 03/2005
2Protein Kinases (Protein Kinase)IBA
10/2007 - 09/2007
2Androgen Antagonists (Antiandrogens)IBA
12/2003 - 06/2003
2SteroidsIBA
03/2003 - 02/2002
1Protein Isoforms (Isoforms)IBA
12/2017
1TCF Transcription FactorsIBA
12/2017
1CateninsIBA
12/2017
1ATP dependent 26S protease (26S proteasome)IBA
10/2017
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2017
1EnzymesIBA
01/2017
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2017
1UbiquitinIBA
01/2017
1Ligases (Synthetase)IBA
01/2017
1MicroRNAs (MicroRNA)IBA
05/2016
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/2016
1LuciferasesIBA
01/2016
1Pharmaceutical PreparationsIBA
01/2016
1PTEN Phosphohydrolase (PTEN Phosphatase)IBA
11/2014
1Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
11/2014
1GTP Phosphohydrolases (GTPases)IBA
09/2014
1SuspensionsIBA
09/2014
1AldehydesIBA
09/2014
1Phenobarbital (Luminal)FDA Link
09/2014
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
11/2013
1Insulin (Novolin)FDA Link
11/2012
1Insulin Receptor Substrate ProteinsIBA
11/2012
1Insulin-Like PeptidesIBA
11/2012
1E2F1 Transcription FactorIBA
04/2012
1Sp1 Transcription FactorIBA
09/2011
1Scutellaria barbata extractIBA
08/2010
1Cyclin A2IBA
08/2010
1AlkaloidsIBA
07/2010
1Arecoline (Arecolin)IBA
07/2010
1Tight Junction ProteinsIBA
07/2010
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2010
1NF-kappa B (NF-kB)IBA
06/2010
1Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
04/2010
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
10/2009
1rho-Associated KinasesIBA
05/2009
1Selective Estrogen Receptor Modulators (SERM)IBA
02/2009
1Raloxifene Hydrochloride (Evista)FDA Link
02/2009
1Cyclin-Dependent Kinase 4IBA
01/2009
1PhosphofructokinasesIBA
05/2008
1FurinIBA
05/2008
1Immunoglobulin A (IgA)IBA
05/2008
1Glucose (Dextrose)FDA LinkGeneric
05/2008
1CytokinesIBA
05/2008
1Reactive Oxygen Species (Oxygen Radicals)IBA
05/2008
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2008

Therapy/Procedure

5Therapeutics
01/2017 - 02/2008
1Drug Therapy (Chemotherapy)
06/2010